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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '81f29d07de7b62fb0280b7a4ff009a954aa807c0953d892aa7b9b0d4e993be17' 
  AND token = '2IN2KZHejbzLBbYbS6/YfsCpY8SlSJ+uWa38Q1XP6bc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}