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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a8f88a4cf7ca82679cc172a5cd78b063b851e58d6789fa477402aad587009020' 
  AND token = 'EZx9wqwSzdJoAktFo/v2xzWZIUiJxnthhJSU0Io2R3Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}