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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5331e48e4d02898c048eabcf3f20d7148fc98207843ce1728f4ef0c1c09ec079' 
  AND token = 'tQxXSY+9VOX3N5IlOK6cr+0JT/oq2KBIOuJWOmeBLoI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}