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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '849264ec0ce1e658260adf807c5b688a6a21714b3a5797286d0120212afd652f' 
  AND token = 'fhZSCCGQaJQdRs7OO4jeg/WsR4yJUFHwqsGdBnAeGT8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00058

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}