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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c07b481822a9825407fc016f845bc4b4af5008a2066d8d4dd21ac9380fcd8d6d' 
  AND token = 'zkA8Ix651+m+QMeVo7IJUmdxtfXnAIy5L6LMrpgqqRc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}