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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ce4e097e8a27f4c4e457545ae453defba6478209323b41d7897e1b46b05c3630' 
  AND token = '122ps83PGNtDTBEouqrWSzbC2AH28eLS3fv0BEMDXa8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}