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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2021520e886aa2264796337f838d7d2e04a88a29ce5709a72d58f43817f11173' 
  AND token = 's5+mZlo65Q7SUPKQ76SeG2RKCGzBuXRMSrtioZNNKMM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}