SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '61e81f486a813257cf9a6c2e6cfee8117b7366f1c7d69dc5140e5774bf2cf9e8' 
  AND token = 'SNy1n1+/1gN6z0Km8X+v4sOB4XeqVGK4xcJo0nMk+RQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}