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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '281e198909a3a58bf1b86c9966aae53820bdc8435d7002b05e8ebdd8c34b75c1' 
  AND token = 't2WIzrV2apIHSlyd8BFm4memEWEIwCYvS6yuNURt4/k=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}