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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5247ee5338b17ab19e02889bb7431b9d05d4dd765432d32ccdedff7a0677a8b4' 
  AND token = 'GjXlH2oX8XEc3PC8V9xxRDi6Ugyt+fBPCiuVBuYceZE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}