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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '27cf1ed9a54bd88a5c26b844185a1cce95804c0bc5a3f2e366d3f3294fde2430' 
  AND token = '53fMfQIIj7ugcH+ECj/OwxFEk/vHp0QzBfKzeE7X/DI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}