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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4fa3a65ca4d158fe04da07e92340688d0c78d93a1c29ab0550c46187b5236ef4' 
  AND token = 'Jw7Vjj5C+d86xHkLKE+BFrbfSIyRj3SeHojbiRMjPkI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}