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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e797415180c07cfa55d71106b5e826e8d250ce8b6a3bec2a34333ab6aa04bf72' 
  AND token = 'RPUIqQ0fLQAHX8y/WqKi5MtOJa8afYFwGeTHlleKQuQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}