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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f2596641bdd753eb5ff26bc2958093f166d2433be7290acbcf07ed4e3f2bccd5' 
  AND token = 'GcRmh6uUoFP/6PTYL4GGgNFyMt2xDOt9iGH6kCHT7vQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00049

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}