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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4d501942c2f81fce762054eeebbb61faaa2d10f98a52187beb66c5e8a299d817' 
  AND token = 'U3kPZMuikcPDx6zO2t8ejFtqxiMQmghJwztYNrB01D0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}