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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6e46b439a1b4e2b6e1cfeae148546b9723fb33446d68d326990b1811448b8799' 
  AND token = 'J+xS0hzzdq8X4ZYcNDFH60DTLZiszkTKmGnhSztPEAE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}