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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49c1844fb8e19f331d8b2dfd27caa61bdd3df1e8d9d586c0a4922b231d4701da' 
  AND token = '5VYv7f7KleO7l6wB3JBG3LDvt1enb0j1ZiPiA+mKbiQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}