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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2049701ac19f4a7cf1af5a491bace9d376b99507f0f57a06d4d0f22584e4664e' 
  AND token = 'TNPMZz9cU2H4c0L2HjoH8MX3JsPMCJXEpgbfqIXzd7E=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}